Stem cell-based therapy for inflammatory bowel disease
نویسندگان
چکیده
منابع مشابه
Inflammatory bowel disease: Moving toward a stem cell-based therapy.
The incidence and prevalence of Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel diseases (IBD), are rising in western countries. The modern hygienic lifestyle is probably at the root of a disease where, in genetically susceptible hosts, the intestinal commensal flora triggers dysregulated immune and inflammatory responses. Current therapies ranging fr...
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IBD: Inflammatory Bowel Disease ; UC: Ulcerative Colitis; CD: Crohn’s Diseases; TNF-α: Tumor Necrosis Factor α; IL12/23: Interleukin 12/23; IL-6R: Interleukin 6R; iRNA: information Ribonucleic acid; SC: Stem Cells; CT: Cell Therapy; MSC: Mesenchymal Stem Cells; HSC: Hematopoietic Stem Cells; 2,4,6-TNBA: 2,4,6-Trinitrobenzene Sulfonic Acid; SDF-1: Stromal Derived Factor-1; VEGF: Vasculoendotheli...
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Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is a chronic, recrudescent disease that invades the gastrointestinal tract, and it requires surgery or lifelong medicinal therapy. The conventional medicinal therapies for IBD, such as anti-inflammatories, glucocorticoids, and immunosuppressants, are limited because of their systemic adverse effects and tox...
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Despite all of the advances in our understanding of the pathophysiology of inflammatory bowel disease (IBD), we still do not know its cause. Some of the most recently available data are discussed in this review; however, this field is changing rapidly and it is increasingly becoming accepted that immunogenetics play an important role in the predisposition, modulation and perpetuation of IBD. Th...
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ژورنال
عنوان ژورنال: Intestinal Research
سال: 2019
ISSN: 1598-9100,2288-1956
DOI: 10.5217/ir.2019.00043